Ongoing from recently collected knowledge about the underlying mechansims of the lectin-cell interaction, the Smart Drug Delivery & Preclinical Pharmaceutics-group develops and evaluates labelled and surface-functionalized micro- and nanoparticles made from biodegradable polymers as well as soluble macromolecular prodrug-systems. Besides optimisation of manufacturing parameters special emphasis is given to the particle-cell interaction. The currently established human cell culture models comprise artificial intestinal epithelium, prostate cancer, bladder and bladder cancer, breast-carcinoma, chondrocytes, macrophages, vascular endothelial cells as well as primary cultures.
Currently, research efforts focus on development of innovative bioadhesive formulations for therapy of urinary tract infections and bladder cancer as well as systems for drug delivery to the middle and the inner ear. At this, the approaches rely on specially designed constructs considering the type of cargo, the charge, and the surface-decoration.
Within the BioNanoNet IPB offers the technological development of particulate matter and its physico-chemical, nanotoxicological as well as preclinical characterisation.
There is a growing socio-economic need for effective and reproducible strategies to repair musculoskeletal tissues. In particular, acute tendon injuries and chronic tendinopathies remain clinically challenging, partly due to the low number of tissue-resident cells. Further, the avascular nature of tendons delays healing, whilst the innate reparative processes are incomplete and are often associated with the formation of scar tissue that compromises mechanical function and causes pain. In contrast, bone generally is effectively repaired after damage through an innate regenerative process, in most cases resulting in full restoration of a functional tissue with no apparent scar formation. However, around 10% of all fractures do not heal adequately and especially large osseous defects after trauma, prosthesis loosening, or tumor resection, remain clinically challenging.
Despite significant advancements in regenerative medicine and tissue engineering (e.g. sophisticated combination of scaffolds, cells, and biologics) the clinical impact for the regeneration of tendon and bone remains limited. For the development of functional reparative therapies, we need to pin down the molecular and cellular mechanisms amenable to modulate endogenous (or exogenous) cell behavior towards functional repair and regeneration. By investigating the developmental programs driving tendon and bone tissue formation and, on the other hand, the mechanisms contributing to their senescence, ultimately resulting in decreased quality of tendons and bones in the elderly, novel targets for clinical intervention potentially can be discovered.
The Institute of Electrical and Biomedical Engineering was founded as an academic unit at the Department of Biomedical Informatics and Mechatronics in September 2009. The goal of the Institute of Electrical and Biomedical Engineering (former Institute of Electrical, Electronic and Bioengineering) is to advance fundamental understanding of how electrical and biomedical systems operate and to develop effective technologies for applications across a wide spectrum in mechatronics and biomedical engineering.
Collaborations with international research institutions and industry offer unique opportunities for the electrical and biomedical engineering discipline. Located at the UMIT/EWZ campus in Hall in Tyrol, the institute does have strong local collaborations with the Leopold-Franzens University Innsbruck, the Innsbruck Medical University and the Tyrolean industry.
The Ludwig Boltzmann Institute for Experimental and Clinical Traumatology has been the core of the Austrian Cluster for Tissue Regeneration since 2006 which was further enlarged in 2013/2014 (see our information brochures at the attachment). The Research Center is located in the Lorenz Böhler Trauma Center in Vienna, Austria. In 2003, a satellite laboratory was established in Linz, Upper Austria, devoted to human adult stem cell research; the laboratory operates in conjunction with the Red Cross Bloodbank of Upper Austria.
The primary objective of the Center for Traumatology Research is to improve diagnostic and therapeutic measures in trauma care specifically in the area of intensive care (Prof. Soheyl Bahrami) and tissue regeneration (Prof. Heinz Redl). Interdisciplinary cooperation allows the Center to be engaged in many fields of medicine, stemming not only from diverse research projects, but also analysis of international research results and their practical application within the AUVA (clinical studies and Continuing Education). Furthermore, the Research Center is involved in numerous Austrian and European research projects
Head: Prof. Erika Jensen-Jarolim, MD The research unit represents a strong bridge from human to veterinary medicine. Accordingliy the team is active at two universities:
More than 40 scientists work today in the laboratories. The development of novel vaccines agains allergies and cancer is in the focus of research, with special emphasis on nanotechnology. Laboratory 1 was opened in spring 2013 only and is best equipped not only with standard device, but also high-end devices such as the automated laser scanning microscope Tissue FAXs from Tissue Gnostics, Vienna, a Becton Dickinson FACS Canto II equipped with the latestsoftware and two lasers, an ISAC ImmunoCAP microchip scanner for molecular allergy diagnosis. Methods comprise biochemical and immunological Assays, immunohistochemistry, protein and antibody expression and purification, as well as all state of the art in vitro methods in allergy and cancer research.
Univ.Prof. Dr. Erika Jensen-Jarolim, firstname.lastname@example.org, phone: +43 1 40400 51100
The Chair of Polymer Processing at the Montanuniversitaet Leoben is an internationally recognized research institution working in the field of polymer engineering and science. The five key aspects of activity are i) injection molding, ii) extrusion and compounding, iii) polymer nanocomposites and nanotechnology, iv) rheological and thermodynamic material properties and v) simulation. The chair addresses issues that treat current basic as well as applied research, such as nanotechnology, polymeric paper, waste utilization, energy savings, process optimization, product development, quality control, and questions on the wear of metallic materials in the processing machines and molds. For the execution of research projects various laboratory as well as semi-industrial scale machinery, such as injection molding machines or single and twin-screw extruders, as well as fully equipped laboratories for material data evaluation and simulation are available. The Chair of Polymer Processing with its human resources and facilities is able to perform complex state of the art research in the field of polymer engineering and science as well as related, e.g. medical engineering or pharmacology, industry and research topics.
The Industrial Liaison Department is the contact point for companies and business relation at the Montanuniversitaet Leoben. The focus of its activities lies on finding solutions for industrial problems and research challenges related to the expertise and research areas of the Montanuniversitaet. Networking and establishing cooperations between company partners, research institutions and the departments of the Montanuniversitaet are the main tasks of the members of the Industrial Liaison Department. Additional expertise lies in the definition and management of R&D projects, the consulting in funding issues, questions of IPR management or entrepreneurship. The Industrial Liaison Department offers together in cooperation with the Technology Academy of the Montanuniversitaet highly specialised lifelong learning and training in the field of frontier engineering topics.
PROFACTOR is a private, applied research company with headquarters in Steyr and Vienna.
Our scientists research and develop industrial production technologies. The Society to promote the modernization of production technologies in Austria (Vereinigung zur Förderung der Modernisierung der Produktionstechnologie in Österreich or VPTÖ for short) founded PROFACTOR in 1995. In April 2014, the Upper Austrian Research (UAR) has taken over 60 percent of the shares of PROFACTOR GMBH. More than 1,240 completed projects with more than 400 satisfied partners and customers have made us to Austria’s no. 1 in applied production research.