The Medical Sensor Solutions group has expertise in the following areas:

  • medically relevant issues and work-flow compatibility (of medical applications)
  • scientific and technological expertise with respect to different measuring systems and methods
  • system integration and reformulation of medical needs to provide technical solutions for implementing a product
  • market overview and market knowledge

Medical Sensor Solutions develops sensor technologies for the determination of blood gases, DNA, proteins, metabolites, ions, and pathogens for diagnostics in the areas of:

  • pre-operative care
  • during surgery
  • post-operative care
  • homecare (ambient assisted living)

Implementation of sensor technology

MSS has the major goal to utilize and transfer technologies for medical needs and to apply these technologies for the benefit of the patient.

Sensors have been successfully applied in the following areas:

  • Minor or non-invasive glucose monitoring in
    • home care
    • hospital care
  • Glucose control for the intensive care medicine and during surgery 
  • Intelligent dialysis – continuous monitoring during dialysis (continuous measurement of electrolytes such as sodium, potassium, calcium, phosphate, low-molecular heparin, coagulation factors, etc. during therapy)
  • Self-measurement of potassium  (possibly sodium) for kidney and heart diseases – medication has a strong influence on the potassium level
  • Rapid analytical test for acute ill persons for POC devices (e.g., cardiac infarction (Troponin T), blood gases and electrolytes, myoglobin and D-Dimer in combination with troponin T)  
  • Blood gas analysis rapid test as screening parameter
  • Breathing air analysis – spectroscopic metabolomics
  • Multiparameter analysis in the central nervous system
    • either in combination or exclusive of open flow microperfusion
    • brain: EEG, CO2, O2¸ pharmacological substances, cerebral compression
    • transplanted organs (lever, kidney, …): 10% of organs loose their functionality during transplantation – early discovery by parameter monitoring such as CO2, O2, lactate, hemodynamic parameter (capillary circulation)
    • online-monitoring in blood (O2, CO2, potassium, sodium, calcium, glucose)
    • during surgery
  • Intelligent infusion technology – combines sensortechnology with infusion control in intensive care medicine (potassium, O2, CO2, pH, lactate)
  • Sensor development for industrial partners
    • e.g., to control heart-lung-machines (pO2 and pCO2)
    • breathing gas analysis 
  • Imaging in diagnostics with tomographic techniques
    • transcutaneous and 2-D measurement of pH and O2 for perfusion screening
    • observation of trauma healing
    • ultrasonic probes for open flow microperfusion (OFM) for determination of blood circulation 

Expertise

Medical expertise:

  • Patient care
  • Clinical work-flow
  • Identification of medical needs
  • Preclinical study centre (ISO 9001:2000)
  • Clinical study centre (Phase 1-3, GCP)
  • Therapy decisions for „closed loop systems“
  • Translation of medical needs into technological solutions
  • Internationally renowned experts in different areas of medicine e.g., neurology, surgery, endocrinology, oncology, etc.


Scientific expertise:

  • Materials science
  • Optical spectroscopy
  • Electroanalysis
  • Inorganic and organic syntheses
  • Plasmon resonance
  • Genomics, proteomics, metabolomics
  • Nanoparticle technology

Technological expertise:

  • Semiconductor technology
  • Medical device engineering (ISO 13485)
  • Catheter development
  • Signal processing and amplification
  • Data management
  • Integrated circuits
  • Integrated optics and fiber optics
  • Array technology
  • Micro- and nanostructuring

In the future, the current expertise portfolio shall be extended in the following areas:

  • Biocompatibility
  • Algorithms and software development
  • Synthesis of selective receptors

The expertise and skills listed above enable the realization of solutions for a broad range of problems related to medical sensor technology. A few examples are:

  • Blood gas analysis
  • Control of heart-lung machines
  • Glucose monitoring for diabetes patients (artificial pancreas)
  • Glucose monitoring for intensive care units
  • Pathogen chips for diagnostics of infectious diseases
  • Breath gas analysis (monitoring of patients during and after surgical treatments, identification of disease patterns)
  • Transcutaneous, two-dimensional pO2 measurement (photodynamic therapy, transplantation surgery)
  • Invasive sensors for surgery control
  • Analytical tests for home monitoring (e.g. cardiac markers)
  • Combination of sensor technology and infusion technology in stationary settings

A few examples of collaborative activities in this research area are shown in the following projects: Careman (www.careman.uni-tuebingen.de), Clinicip (www.clinicip.org), i-Kath, ISOTEC (www.isotec-cluster.at), Nano-Health (www.nano-health.at). More information on these projects can be found in the category "reference projects". In addition, the foundation of a R&D office of BBraun in Graz deserves special attention because it resulted from a close cooperation of scientific partners from the Technical University of Graz, Medical University of Graz and JOANNEUM RESEARCH.